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Fig. 5. Differentiated lineage analysis in intestinal mucosa: commitment to the
Paneth cell lineage. (A) Villin, UEA-1 and chromogranin staining in sections
from control and mutant mice on day 4. Arrows indicate chromogranin-positive
cells. (B) H&E and ß-catenin staining of the crypt compartment of
control mice (a,f). Arrows indicate Paneth cells (a) and nuclear
ß-catenin staining in the Paneth cells (f). In situ hybridization of
lysozyme and cryptdins in the small intestine of control mice (b,g), in colon
polyps from APC+/- mice at low (c,h) and high magnification (d,i),
and in the small intestine of mutant mice (e,j) at day 4.
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