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Fig. 5. Tooth abnormalities in Nestin cre;Bmpr1a n/f mutant embryos
compared with stage-matched wild-type embryos. (A-D) Coronal sections of 16.5
dpc maxillary and mandibular molars. Genotypes and tooth types are labeled. In
wild-type embryos (A,B), the maxillary and mandibular molars are in the cap
stage of development, whereas in Bmpr1a mutants, the maxillary molar
is at the bud stage of tooth development (arrow in C). The Bmpr1a
mutant mandibular molars (D) are at the same stage of development as in the
wild-type (B). Scale bar: 100 µm. (E-H) Coronal sections of maxillary and
mandibular incisors at E16.5. Genotypes and tooth type are labeled. The
developing maxillary and mandibular incisors are seen in the wild-type embryos
but in the mutant the maxillary incisors are absent. In addition, there is a
cleft of the primary palate (asterisk, G). Scale bar: 100 µm. (I,J) At
E18.5 in the wild-type embryos, the maxillary and mandibular molars have
progressed to the more advanced (bell) stage of development. (K) At 18.5 dpc,
in the Bmpr1a embryos, the maxillary molars are still in the bud
stage of tooth development (arrow). (L) The mandibular molars in 18.5 dpc
mutants are at the cap stage of tooth development (arrow). I, incisor; mo,
molars; mc, Meckel's cartilage; ns, nasal septum; t, tongue. Scale bars in
I-L: 100 µm.
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