QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online March 4, 2005

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Nmyc controls balanced lung development

During organ development, a delicate balance between proliferation and terminal differentiation of progenitor cells ensures that the final organ has the correct size and structure. On p. 1363, Okubo and co-workers report that Nmyc is required to maintain this balance in developing mouse lungs. They show that Nmyc expression in mouse embryonic lung is restricted to a distal population of undifferentiated epithelial cells, many of which are in the S phase of the cell cycle. Overexpression of Nmyc in the epithelium of the developing lung increases the domain of S phase cells and inhibits differentiation; deletion of one or two copies of Nmyc produces the opposite outcomes. Thus, the researchers suggest, Nmyc's role in lung development is to maintain a distal population of undifferentiated, proliferating progenitor cells, a discovery that may help us to understand disorders such as lung cancer.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

Tadashi Okubo, Paul S. Knoepfler, Robert N. Eisenman, and Brigid L. M. Hogan
Development 2005 132: 1363-1374. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?