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First published online March 4, 2005

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Spacing neural development

The spatial regulation of neuorogenesis is a mysterious but crucial process in vertebrate central nervous system development. In zebrafish embryos, proneuronal domains, which produce early neurons, are separated by inter-proneuronal domains, which do not undergo neurogenesis until later in development. On p. 1375, Bae and colleagues report that the hairy- and enhancer of split-related genes her3 and her9 link positional information in the posterior neuroectoderm to the spatial regulation of neurogenesis. The expression of her3 and her9 is restricted to inter-proneuronal domains, and inhibiting either of their functions with antisense morpholinos causes the ectopic expression of proneural genes in these domains. Inhibiting both proteins' functions abolishes inter-proneuronal domain formation. Other results indicate that her3 and her9 expression is regulated by positional information in which Bmp signalling is involved. The researchers conclude that her3 and her9 spatially control neurogenesis by functioning as prepattern genes.

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Related articles in Development:

Patterning of proneuronal and inter-proneuronal domains by hairy- and enhancer of split-related genes in zebrafish neuroectoderm

Young-Ki Bae, Takashi Shimizu, and Masahiko Hibi
Development 2005 132: 1375-1385. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?