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Fig. 1. Sequence and expression pattern of SRp38. (A) Schematic diagram of SRp38. SRp38 is a 238 amino acid protein with an N-terminal RNA recognition motif (RRM) containing two conserved ribonucleoprotein (RNP) domains and a C-terminal serine-arginine rich (SR) domain. RNPs are underlined in red and SR domain is underlined in blue. (B) The RRM of SRp38 is 87% identical to that of the mouse SRp38 isoforms (TASR1 and TASR2). The SR domain is low complexity and the homology drops considerably in this region. (C-F) Expression pattern of SRp38. (C,E) Dorsal view. (D,F) Lateral views. (C,D) At stage 15, SRp38 is expressed diffusely throughout the neural plate. (E,F) At later stages, SRp38 is expressed in the anterior of the embryo, throughout the neural tube, eyes and branchial arches, and surrounding the otic vesicle.





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