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Fig. 9. Pre-placodes form from an unspecified placodal field independent of
Hedgehog. (Bottom) At neural plate stages, pitx3 (blue) and
dlx3b-dlx4b (red) expression domains demarcate placodal fields (Figs
2,
3). (Middle) Lens and pituitary
pre-placode forms in a Hedgehog-independent process and has lens epithelial
character (light blue). (Top) In a Hedgehog-dependent process, pituitary
tissue (green) is specified (Figs
7,
8)
(Herzog et al., 2003;
Karlstrom et al., 1999;
Kondoh et al., 2000;
Sbrogna et al., 2003;
Treier et al., 2001;
Varga et al., 2001).
Similarly, lens epithelial cells (light blue) differentiate into lens fiber
cells (dark blue) under influence of BMPs
(Belecky-Adams et al., 2002;
Faber et al., 2002).
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