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Fig. 1. Expression of Tbx15 at E10.5. (A) Expression of Tbx15 in
wild-type forelimb bud at E10.5. (B) Expression of Tbx15 in hindlimb
bud at E11.5. (C) Pax1 expression in wild-type forelimb bud at E10.5.
Note that the expression of Pax1 in the shoulder-forming region is
complementary with that of Tbx15. (D,E) Alx4 expression in
wild-type (D) and Gli3–/– (E) forelimb buds at
E10.5. In Gli3–/– limb buds, Alx4
expression is downregulated in the distal part of its normal expression
domain. (F-I) Expression of Emx2 in wild-type (F,H),
Alx4–/–/Cart1–/–
(G) and
Gli3–/–/Tbx15–/–
(I) forelimb buds at E10.5. (J) Tbx15 in situ hybridization on a
wild-type sagittal section at E10.5. Black arrow indicates expression in
notochord and surrounding mesenchyme. (K,L) Tbx15 in situ
hybridization on wild-type transverse sections at E10.5. (K) Black arrowhead
shows expression of Tbx15 in lateral cranial mesenchyme. (L) Higher
magnification of section shown in K showing expression of Tbx15 in
notochord (black arrow) and surrounding mesenchyme. a, atrium; m, mandibular
component; mx, maxillary component of first branchial arch; v, ventricle.
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