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Fig. 2. Skeletal abnormalities of Tbx15 mutants. Alcian Blue and Alizarin
Red staining of newborn and E13.5 wild-type and Tbx15 mutants. (A)
Newborn Tbx15 mutants have a foramen in the blade of the scapula and
the humerus is shorter than in wild type. (B,C) Alcian Blue staining of E13.5
wild-type (B) and Tbx15 mutant (C) shoulder girdle. At this stage the
phenotype is already present. (D) Abnormalities of the caudal posterior aspect
of vertebrae in newborn Tbx15 mutants. Arrow indicates ectopic
cartilage in the atlas of Tbx15 mutant; arrowhead indicates the place
were the dens of the axis is missing. (E,F) Cranial base of a newborn
wild-type (E) and Tbx15–/– (F) skull. The
Tbx15 mutant skull is shorter and narrower than the wild type, and
the basioccipital bone (B) is narrow when compared with wild type; also the
inner ear (I) has an abnormal medial and caudal position.
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