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Fig. 12. Chromatin-remodeling factors facilitate distinct stages of transcription.
The stage at which each chromatin-remodeling factor is hypothesized to
function is marked by an unbroken line. BRM physically interacts with
transcriptional activators and facilitates a step prior to the recruitment of
Pol II to promoters. CHD1 has been implicated in the later stages of
transcriptional elongation. Our findings suggest that KIS-L is required for
the transition from the early to late stages of elongation. The activities of
KIS-L and CHD1 may be influenced by the methylation of histone H3 lysine 4 and
lysine 36 near the 5' end and in the body of transcribed genes,
respectively.
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