spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 2. Super-repressor I{kappa}B-{alpha} reduces neurite growth from neonatal nodose neurons but does not affect survival. P1 nodose neurons were transfected with a YFP expression plasmid together with either a super-repressor I{kappa}B-{alpha} plasmid or an empty control plasmid and were incubated in medium containing 10 ng/ml BDNF. Control transfected neurons were also grown without BDNF. (A) Percent survival 48 hours after transfection. (B) Total neurite length 24 hours after transfection. (C) Number of branch points in neurite arbors 24 hours after transfection. (D) Sholl analysis of neurite arbor morphology 24 hours after transfection. (E) Photomicrograph of a typical control transfected neuron grown for 24 hours with BDNF. (F) Photomicrograph of a typical super-repressor I{kappa}B-{alpha} transfected neuron grown for 24 hours with BDNF. Scale bar: 50 µm. The means and standard errors of data obtained from 40-70 neurons in each experimental condition shown. Statistical comparisons shown are with respect to the control transfected neurons, *P<0.05, **P<0.001.





Right arrow Return to article