spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 1. Notch signaling involves regulated-intramembrane proteolysis. Upon ligand binding, N undergoes two successive proteolytic cleavages (Brown et al., 2000). The first cleavage at the S2 site is ligand induced and generates an activated membrane-bound form of N (blue) that is further processed at the S3 site by the {gamma}-secretase complex. This leads to the release of the NICD. The association of the NICD with DNA-bound CSL factors disrupts CSL-co-repressor (R) complexes and promotes the assembly of CSL-co-activator (A) complexes, thereby mediating a transcriptional switch. DSL ligands (pink) can be similarly processed, first at extracellular sites (S2) and then at an intramembrane S3 site by the {gamma}-secretase complex (see text for details). CSL, CBF1, Suppressor of Hairless, Lag-1; Dl, Delta; N, Notch; NECD, Notch extracellular domain; NICD, N intracellular domain; Ser, Serrate.





Right arrow Return to article