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Fig. 5. Regulation of N signaling during asymmetric cell division. (A) The cell
fate determinants Neur (blue) and Numb (pink) are unequally segregated during
the asymmetric division of the sensory organ precursor cell (SOP or pI) in
Drosophila and are inherited by the pIIb daughter cell.
-Adaptin (green) binds to Numb and is enriched at the anterior cortex
of the dividing pI cell. (B) In the pIIb cell, the interaction of Numb with
-Adaptin has been proposed to promote clathrin-mediated endocytosis of
either N and/or Sanpodo to endosomes (E). Neur binds Delta (Dl), ubiquitinates
it and promotes its endocytosis in the pIIb cell. It is not known whether the
endocytosis of Dl is AP2-dependent. The endocytosis of Dl in pIIb leads to the
activation of N in the pIIa cell. A possible role of Wasp in endocytosis may
be to promote Dl internalization.
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