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Fig. 1. Ectopic HLH-1 activity converts most somatic blastomeres to a body wall
muscle-like fate. (Left) Diagrams of wild-type embryos at the comma stage of
development [adapted from Sulston et al.
(Sulston et al., 1983)] with
four different cell type patterns highlighted by nuclei or tissue area
shading; body wall muscle (BWM), intestine (Int); hypodermis (Hyp) and pharynx
(Phar). Adjacent to each diagram is a wild-type embryo stained with an
antibody recognizing the corresponding tissue and imaged in a single focal
plane. The far right column shows terminally arrested embryos in which HLH-1
activity was induced in early development by heat shock treatment. All embryos
showed widespread myogenesis as indicated by MHC A staining in a
representative focal plane from throughout the embryo (top) and a complete
lack of staining for markers of the intestine, hypodermis and pharynx (below).
All images in this and subsequent figures are a single focal plane
deconvoluted using Hyguens software.
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