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Fig. 1. Abl, trio and ena interact genetically with fra
and the Netrin genes. CNS axons were labeled with mAb BP102, and
stage 14-16 embryos were dissected and scored for defects. (A) In wild-type
embryos, CNS axons are organized into two commissures per segment (AC and PC),
and two longitudinal tracts that run the length of the nerve cord on either
side of the midline. (B-T) In mutant embryos (genotypes are indicated in the
figure), commissure formation is defective. Examples of segments with thin or
missing commissures are indicated with arrows in F-H,P and T. Examples of
segments with errors in commissural axon pathfinding are indicated with
arrowheads in C,H,I,R and S. Examples of breaks in longitudinal pathways are
indicated with asterisks in F,H,L,N and O. D,L and N are examples of moderate
trio,Abl, fra;Abl, and fra;trio phenotypes, respectively,
whereas E,M and O show severe phenotypes. Df(2R)vg135 and
Df(3L)FpaI are deficiencies for fra and trio,
respectively. Df(1)NP5 removes both NetA and NetB.
Anterior is to the top of each image. Scale bar in A: 
25 µm.
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