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Fig. 2. Heterozygosity for Abl, trio and ena reduces the severity of inappropriate midline crossing by axons expressing the chimeric Robo-Fra receptor. A subset of longitudinally projecting axons in stage 17 embryos were labeled with mAb 1D4 (anti-Fas2). Examples of Fas2-positive bundles scored as ectopic crossovers are indicated with arrows. (A) In wild-type embryos, Fas2-positive axons project in three distinct longitudinal bundles on either side of the CNS midline, but never cross the midline. (B) In embryos expressing UAS-Robo-Fra under the control of the ELAV-GAL4 postmitotic neuronal driver, numerous Fas2-positive axon bundles cross the midline, reflecting inappropriate attraction towards the midline repellent Slit. (C) In embryos heterozygous for Abl and trio, fewer axon bundles cross the midline. (D) Heterozygosity for Abl and ena also reduces the severity of the Robo-Fra phenotype.





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