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Fig. 6. Expression of Axin2 in developing skull. The Axin2
expression pattern was visualized by ß-gal staining in whole mounts (A-H)
or sections (I-L). Axin2 is present in metopic and coronal sutures at E16.5
(A,E,I). Axin2 is detected at high levels in the osteogenic fronts
(arrowheads), periosteum (asterisks) and mesenchyme of the sutures, as well as
in the nasal bone (arrows) and nasal cartilage. At P4, Axin2 is
highly expressed in the osteogenic fronts (arrowheads), periosteum
(asterisks), nasal bone (arrows) and nasal cartilage (B,F,J). At P14, high
levels of Axin2 are observed in nasal and frontal bones (C,G) in addition to
the osteogenic fronts (arrowhead) and periosteum (asterisks; K,L). By P31,
expression of Axin2 appears to be diminished to very low levels (D,H). First
and second rows, the Axin2lacZ allele shows Axin2
expression. Third row, coronal sections of the ß-gal stained metopic
sutures, counterstained with nuclear Fast Red. Scale bars: 3 mm in A,H; 5 mm
in B-D; 1 mm in E,F; 2 mm in G; 100 µm in I-L.
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