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Fig. 8. Alteration of the canonical Wnt pathway in the Axin2 mutants during skull morphogenesis. Sections of the Axin2+/+ (A,C,E) and Axin2–/– (B,D,F) sutures were immunostained with the primary antibody (brown) and counterstained with Hematoxylin (blue). Immunohistochemical staining with an antibody that recognizes only the activated form of ß-catenin ({alpha}-ABC antibody) reveals stimulation of ß-catenin signaling (arrowheads) in the Axin2–/– suture at P8 (B) and P28 (D). Expression of cyclin D1, a bona fide target of ß-catenin, is also elevated in the Axin2–/– suture (broken lines) at P8 (F). Scale bars: 50 µm in A,B,E,F; 25 µm in C,D.





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