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First published online March 24, 2005

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Notch one up to Wnt signalling

The stability and intracellular localisation of ß-catenin (also known as Armadillo in flies) is a central control point in Wnt signalling. Now, on p. 1819, Hayward and co-workers report a surprising way in which the activity of Armadillo/ß-catenin might be regulated – by Notch. Their genetic and biochemical experiments in developing Drosophila and in cultured fly and mouse cells indicate that Notch modulates Wnt signalling – an idea that has previously attracted some controversy – by regulating Armadillo/ß-catenin activity. This regulation occurs independently of the interaction of Notch's active intracellular domain with Suppressor of Hairless, an interaction needed for the transcriptional regulation of many of Notch's previously recognised targets. The researchers suggest that the modulation of Armadillo/ß-catenin activity by Notch both establishes a threshold for Wnt signalling and stringently regulates activated Armadillo/ß-catenin, a function that is relevant to Notch's tumour suppressor role in mouse skin.

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Notch modulates Wnt signalling by associating with Armadillo/ß-catenin and regulating its transcriptional activity

Penny Hayward, Keith Brennan, Phil Sanders, Tina Balayo, Ramanuj DasGupta, Norbert Perrimon, and Alfonso Martinez Arias
Development 2005 132: 1819-1830. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?