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Fig. 4. IrreC-rst colocalises with DE-cadherin in the zonula adherens. (A-C) In the wild-type retina at 30% p.d., DE-cadherin (green) marks the apical region of all accessory cells, cone cells, primary pigment cells, IOCs and bristles (see also Fig. 3B). At this stage and later (Fig. 3J), IrreC-rst (violet) accumulates almost exclusively at the borders between primary pigment cells and IOCs (1°/IOC). DE-cadherin and IrreC-rst colocalise at the border between IOCs and primary pigment cells. (D-F) Longitudinal sections through a wild-type retina at 35% p.d. confirm the colocalisation in the apical region of the pigment cells, at the site of the adherens junctions. DE-cadherin is also found at the adherens junctions of the photoreceptor cells (arrowhead), which have not yet begun to elongate. (G-I) Retina overexpressing Crb_intra at 30% p.d. DE-cadherin (green) and IrreC-rst (violet) colocalise at the border between IOCs and primary pigment cells. The staining pattern is nearly the same as in wild type, showing only a few interruptions. (J-L) Longitudinal sections through a Crb_intra-overexpressing retina at 38% p.d. confirm the colocalisation of IrreC-rst and DE-cadherin in the apical region of the pigment cells, at the site of the adherens junctions. The structure of the adherens junction of photoreceptor cells (arrowhead) is less regular than in wild type.

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