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Fig. 2. dronc mutants suppress the GMR-hid- and GMR-reaper-induced small-eye phenotype in recessive clones. (A) The unsuppressed GMR-hid ey-FLP (GheF) eye ablation phenotype. (B) Suppression of the GheF phenotype in ey-FLP/FRT-induced clones of dronc^I24. The exact genotype of this fly is GheF/w; dronc^I24 FRT80/w⁺ FRT80. This dronc allele gives rise to strong suppression of GMR-hid and is molecularly a null allele. Similar results were obtained for dronc^I29 and dronc². Despite the fact that mutant clones are phenotypically w^– (see Fig. 1), these flies still produce red eye pigment because the GMR-hid transgene is marked with w⁺ (not indicated in Fig. 1). (C) Suppression of the GheF phenotype in ey-FLP/FRT-induced clones of dronc^L32. The exact genotype of this fly is GheF/w; dronc^L32 FRT80/w⁺ FRT80. This dronc allele gives rise to medium-strong suppression of GMR-hid, and is thus a hypomorphic allele. (D) dronc mutants fail to dominantly modify the GMR-hid eye ablation phenotype. The genotype of this fly is GheF/w; dronc^I24 FRT80/+. (E) The unsuppressed GMR-reaper ey-FLP eye ablation phenotype. Genotype of this fly: ey-FLP/w; CyO, 2xGMR-reaper/+. (F,G) Suppression of GMR-reaper in ey-FLP/FRT-induced clones of dronc^I24 (F) and dronc^L32 (G). Genotypes: ey-FLP/w; CyO, 2xGMR-reaper/+; dronc^I24 FRT80/w⁺ FRT80 (F) and ey-FLP/w; CyO, 2xGMR-reaper/+; dronc^L32 FRT80/w⁺ FRT80. (H) Partial restoration of the GMR-hid eye ablation phenotype in dronc mutant clones by a dronc⁺ transgene. The genotype of this fly is GheF/w; GMR-Gal4/+; dronc^I29 FRT80 UAS-proDronc/w⁺ FRT80.

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