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Fig. 2. Chromatin decondensation at Hoxb during early embryogenesis. (A) FISH of Hoxb1 (red) and Hoxb9 (green) on nuclei from extra embryonic mesoderm (EEM) and primitive streak/adjacent mesoderm (PSM) of one E7.5 embryo. Nuclei were counterstained with DAPI (blue). Scale bar: 2 µm. (B) Distribution of squared interphase distances (d2) in µm2 measured between probes for Hoxb1 and Hoxb9, on nuclei from EEM and PSM of one E7.5 embryo, and in ES cells differentiated with RA for 2 days.





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