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First published online April 13, 2005

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A rotating view of inner ear patterning

Early in its development, the vertebrate inner ear acquires axial identities from the tissues surrounding it. These subsequently influence the development of all the inner ear components. On p. 2115, Bok and co-workers report that the hindbrain determines dorsoventral (DV) but not anteroposterior (AP) axial specification in the chick inner ear. By rotating the hindbrain around its AP axis, the researchers show that the induction of the otic placode - which gives rise to the inner ear - precedes axial specification and that reversing the AP orientation of the hindbrain before axial specification does not affect inner ear development. By contrast, reversing the DV axis of the hindbrain changes the DV axial identity of the inner ear. Additional experiments identify Sonic Hedgehog as one of the hindbrain signals that patterns the ventral axis of the inner ear; the signals and tissues that confer AP axial identity remain unknown.

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Related articles in Development:

Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear

Jinwoong Bok, Marianne Bronner-Fraser, and Doris K. Wu
Development 2005 132: 2115-2124. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?