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First published online April 13, 2005

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A Hym for tentacle formation

Tentacle formation in hydra involves three steps: the specification of body column tissue for the tentacle zone; commitment of spots in this zone to tentacle formation; and, finally, tentacle formation itself. On p. 2225, Takahashi and co-workers reveal that the peptide Hym-301, which was isolated in a screen for peptides regulating hydra development, is involved in controlling the second of these steps. The researchers show that the gene encoding Hym-301 is expressed in the ectoderm of the tentacle zone in adults and in the developing head during bud formation and head regeneration. Treatment of regenerating heads with Hym-301 or with Hym-301 dsRNA alters the number of tentacles formed. These and other results indicate that Hym-301 is involved in axial patterning in hydra and raise the possibility that this and other peptides that affect patterning in hydra may also act as signalling molecules in bilaterians.

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Related articles in Development:

Hym-301, a novel peptide, regulates the number of tentacles formed in hydra

Toshio Takahashi, Masayuki Hatta, Seungshic Yum, Lydia Gee, Masahiro Ohtani, Toshitaka Fujisawa, and Hans R. Bode
Development 2005 132: 2225-2234. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?