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First published online December 8, 2005

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Developing a nervous sweat

Like other parts of the nervous system, the assembly of sympathetic neuronal circuits (which control autonomic bodily functions, including sweating) involves a series of differentiation steps. The final step in sweat gland innervation is a noradrenergic to cholinergic neurotransmitter phenotype switch. Stanke and co-workers now report that target-dependent signalling through the cytokine receptor subunit gp130 mediates this developmental change in the sympathetic neurons that innervate mouse sweat glands (see p. 141). They show that cytokines that act through gp130 are present in sweat glands and that the conditional deletion of gp130 in sympathetic neurons prevents the switch from a noradrenergic to cholinergic neurotransmitter phenotype; the differentiation of cholinergic sympathetic neurons innervating other targets is also mediated by gp130. Surprisingly, gp130-depleted mice have functional sweat glands, indicating that cholinergic neurotransmission is not needed for the acquisition and maintenance of sweat gland secretory responsiveness, as previously believed.

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Related articles in Development:

Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling

Matthias Stanke, Chi Vinh Duong, Manuela Pape, Markus Geissen, Guido Burbach, Thomas Deller, Hugues Gascan, Rosanna Parlato, Günther Schütz, and Hermann Rohrer
Development 2006 133: 141-150. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?