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Fig. 7. Correct apicobasal polarity of myocardial cells requires nok/mpp5. (A) At heart cone stages, myocardial cells are polarized and mostly cuboidal epithelial cells. The junctional marker ZO-1 localizes to the apical side and PRKC (aPKC) just basal of ZO-1 and more diffusely along basolateral membranes. (B) The monolayered epithelial organization of myocardial cells and the correct localization of apicobasal polarity markers is disrupted in nok/mpp5 morphants. However, convergence movements of myocardial cells toward the midline are not affected, suggesting that either epithelial cohesion is not necessary for this type of cell migration or that some epithelial cohesion is maintained.





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