|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 2. Neural tube phenotypes in mouse Hh pathway mutants. (A) In
the wild-type E10.5 embryo, roof-plate cells are specified at the dorsal (D)
midline (dark blue), and dorsal neural progenitors express Pax3 and Pax7
(blue). Six ventral (V) neural cell types are specified, each marked in a
different color (Jacob and Briscoe,
2003). (B) In E10.5 Shh mutants, ventral neural
cell types are absent, V0 and V1 interneurons are present at the ventral
midline, and dorsal progenitor markers are expressed throughout the neural
tube (Chiang et al., 1996;
Wijgerde et al., 2002).
(C) Smo is required cell autonomously for specification of floor plate,
V3, motoneurons (MNs) and V2 cells; for restriction of dorsal fates; and for
the correct positioning of V1 and V0 interneurons
(Wijgerde et al., 2002).
(D) Gli2 mutants lack floor-plate cells and have reduced
number of V3 cells (Ding et al.,
1998; Matise et al.,
1998). (E) V2, V1 and V0 interneurons are expanded dorsally
in Gli3 mutants (Persson et al.,
2002). (F) Gli2/Gli3 double mutants lack both
floor-plate cells and V3 interneurons (Bai
et al., 2004; Lei et al.,
2004; Motoyama et al.,
2003). (G) IFT mutants (Ift172, Polaris and
Dnchc2) lack floor-plate cells, V3 interneurons and nearly all MNs;
V2, V1 and V0 cells are expanded ventrally
(Huangfu and Anderson, 2005;
Huangfu et al., 2003;
Liu et al., 2005). (H)
Ptch1 mutants have a ventralized neural tube
(Goodrich et al., 1997;
Motoyama et al., 2003). No
roof-plate or dorsal progenitor cells are specified, and ventral cell types
are expanded dorsally. (I) Rab23 mutants have a ventralized
caudal neural tube (Eggenschwiler et al.,
2005; Eggenschwiler et al.,
2001). No roof-plate or dorsal progenitor cells are specified, and
ventral cell types are expanded dorsally. (J) Fkbp8 mutants
have a ventralized caudal neural tube
(Bulgakov et al., 2004). No
roof-plate cells are present; ventral cell types are expanded more dorsally
than in Rab23 mutants. Unlike in Rab23 mutant, dorsal
progenitor cells are present.
|
