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Fig. 4. The regulation of Ci/Gli proteins. The full-length Ci protein (gray)
can be proteolytically cleaved to generate a repressor form (blue) or
activated to generate an activator form (red). The vertebrate Gli homologs
share similar domain structures with Ci, but only Gli3 is known to be cleaved
into a functional repressor form. The conserved and diverged aspects of the
regulation of Ci/Gli activation and cleavage are shown. The zinc-finger
domains are indicated by stripes. Components that have been shown either to
promote or to prevent these processes are indicated in the figure. Components
shown in black are common to both vertebrates and invertebrates; those in
yellow are likely to be conserved, but there is insufficient in vivo data to
support their conserved roles; those in purple can play a role in
invertebrates; and those in green function in mouse and zebrafish, but not in
fly. CKI, casein kinase 1; GSK3ß, glycogen synthase kinase 3ß; PKA,
protein kinase A.
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