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Fig. 1. Analysis of En1 expression during calvarial bone development
between E11.5 and P1, as recapitulated by X-gal staining of
En1lki/+ mice. (A,B) Calvarial En1
expression within the craniofacial mesenchyme (Aa-Ac, white arrows) at E11.5
(Aa,Ba), E12.5 (Ab) and E13.5 (Ac,Bb). Expression of En1 during overt
calvarial bone formation (E15.5-P1) is prominent along the osteogenic fronts
(arrowhead) and developing sutures (black arrows) (Ad-Af); it is expressed by
ectocranial periosteal osteoblasts (Ac, Af, asterisks; Bc,Bd, arrow) as well
as by the endosteal osteoblasts and osteocytes of the frontal bone trabeculae
(Bc,Bd, arrowheads). In the interfrontal suture, En1 is expressed in
the mesenchyme (Bc,Be, arrow; Be'), but not in osteoprogenitors
populating the frontal bone margins (Be, arrowheads). By contrast,
En1 is expressed by osteoprogenitors within the coronal suture (Bf,
arrowheads; Bf'). p, parietal bone; f, frontal bone;
e, eye. Scale bars: 2 mm in A; 1 mm in Ba-Bc; 0.1 mm in insets in Ba,Bb, and
in Bd-Bf.
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