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Fig. 2. Npn2 is required to pattern segmental trunk neural crest migration.
Trunk neural crest normally migrates in streams (A) restricted to the
anterior-half sclerotome (B,C). In the absence of Npn2,
segmental migration is lost (D) and neural crest cells migrate
throughout both anterior- and posterior-half sclerotomes (E,F). Neural
crest was visualized at E9.5 by in situ hybridization for Sox10. In
A,D, anterior is towards the left, dorsal is upwards. (B,C,E,F) Longitudinal
sections; B and E are sections through the embryos shown in A and D at the
levels indicated. a, anterior; p, posterior; dm, dermomyotome; sc, sclerotome;
nt, neural tube. Scale bars: 0.1 mm.
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