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Fig. 6. Non-segmentally migrating neural crest cells give rise to segmental
dorsal root ganglia in Npn2 mutant mice. In E10.5 (A) and
E11.5 (C) wild-type embryos, in situ hybridization for Sox10
reveals segmental streams of migrating neural crest cells in the posterior
trunk, and condensed dorsal root ganglia anteriorly. (B,D) In
Npn2 mutant embryos, in the absence of segmental neural crest
migration posteriorly, individualized dorsal root ganglia segregate
anteriorly. Black arrowheads indicate condensing dorsal root ganglia at the
same axial level in all panels. Scale bars: 0.5 mm. (E,F) In sections
of Npn2 heterozygous (E) and mutant (F) E11.5 embryos stained with
anti-TUJ1, dorsal root ganglia had a similar appearance but were less well
separated in the mutant. Scale bar: 0.1 mm.
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