spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Morphogenetic movement defects in developing mouse eyes deficient for RA synthesis. (A-D) Hematoxylin and eosin staining of frontal sections through the eye of E14.5 wild-type (WT), Raldh1-/- (R1-/-), Raldh3-/- (R3-/-) and Raldh1-/-;Raldh3-/- double null (R1;R3-/-) embryos. The double-arrow indicates thickening of the neural retina in R3-/- and R1;R3-/- embryos; notice the lack of a vitreous body and the presence of a retrolenticular membrane in these mutants. (E-H) Expression of RARE-lacZ (an RA-reporter transgene) in whole-mount E10.5 wild-type and mutant embryos. Note the near complete loss of RARE-lacZ expression in eyes of R1;R3-/- embryos. Olfactory pit staining is completely dependent upon Raldh3, but forebrain staining is not dependent upon Raldh1 or Raldh3. c, cornea; D, dorsal; e, eye; el, eyelid; f, forebrain; olf, olfactory pit; pm, perioptic mesenchyme; rlm, retrolenticular membrane; V, ventral; vb, vitreous body.





Right arrow Return to article