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Fig. 9. Neural guidance defects in dgn-1 mutants. Homozygous and
heterozygous dgn-1 mutants have axon guidance, branching and
fasciculation defects in the DA/DB motoneurons (marker:
evIs82[unc-129::GFP]). (A) Approximately 31% of
dgn-1(cg121) homozygotes have side-switching defects in commissural
DA/DB axons, which migrate from the ventral nerve cord (vnc) to the dorsal
nerve cord (dnc). Heterozygotes show side-switching at a lower frequency. In
this cg121/+ heterozygote, the DA6 commissure is abnormally extending
on the right side, while the neighboring DB6 commissure is correctly extending
on the right. (B-D) A variety of other, low penetrance defects are also
seen in dgn-1 mutants. (B) Extra process arising from the neural cell
body (arrowheads). (C) Abnormal axon branching (arrow) and aberrant
anterior/posterior migration of processes (arrowheads). (D) Defasciculation
(arrowhead) of axons in the dorsal nerve cord. Anterior is down in each image.
Scale bar: 10 µm.
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