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Figure 2


Fig. 2. Both heterozygous {alpha}8S50P/+ {alpha}3+/+ and homozygous {alpha}8S50P/S50P {alpha}3+/+ lenses display lens rupture and severely altered fiber cells at weaning age. (A) Lens from an {alpha}8S50P/+ {alpha}3+/+ mouse at P21. (B) Lens from a P21 {alpha}8S50P/S50P {alpha}3+/+ mouse. (C,D) Toluidine Blue-stained lens sections show posterior rupture and severely altered fiber cells in the {alpha}8S50P/+ {alpha}3+/+ (C) and {alpha}8S50P/S50P {alpha}3+/+ (D) lenses of P21 mice. Scale bars: 0.5 mm in the upper panels; 100 µm in the lower panels.





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