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Fig. 6. A model for the cataract formation produced by 
8-S50P
mutation. Normal embryonic and postnatal lenses are formed in the presence
of wild-type 8 (8-WT) and 3 (3-WT) connexins
(following the black arrows). In the absence of 3-WT, the interaction
between 8-S50P mutant connexin (8-S50P) and 8-WT
suppresses the elongation of primary fiber cells in embryonic lenses but does
not affect the formation of secondary fiber cells in postnatal lenses
(following the red arrows). In the absence of 8-WT, the 8-S50P
mutant connexin interacts with endogenous 3-WT to disrupt the formation
of secondary fiber cells in postnatal lenses but does not affect the
elongation of primary fiber cells (following the green arrows).
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