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Fig. 7. An illustration of 
8 connexin (Cx50) protein topology. Known
human mutations are indicated by green squares (R23T, E48K, P88S, I247M) and
an orange oval (V64G) (Shiels et al.,
1998; Berry et al.,
1999; Polyakov et al.,
2001; Willoughby et al.,
2003; Zheng et al.,
2005), and known mouse mutations are indicated by red circles
(G22R, D47A, and S50P) and an orange oval (V64A)
(Chang et al., 2002;
Graw et al., 2001;
Steele et al., 1998). An arrow
indicates the S50P mutation.
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