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Figure 4


Fig. 4. Right ventricular outflow tract (RVOT) morphology of Cx43-WCKO hearts is grossly normal at birth. (A-C) Whole-mount images of control (A), Cx43-WCKO (B) and Cx43fo/fo (germline Cx43-null) (C) neonatal hearts. (D-F) Hematoxylin and Eosin-stained sections from control (D), Cx43-WCKO (E) and Cx43fo/fo (F) neonatal hearts. The Cx43-WCKO RVOT (arrow) appears similar to that of its littermate controls and lacks the infundibular bulging and exaggerated trabeculation (asterisk) seen in germline Cx43 KO hearts. P, pulmonary trunk; RVOT, right ventricular outflow tract. Scale bar: 1 mm.





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