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Fig. 3. Mapping the genome-wide distribution of Polycomb group (PcG) proteins in
mouse and human embryonic stem (ES) cells. PcG proteins form well-known
biochemical complexes: one is PCR2, which contains the H3K27-specific histone
methyltransferase EZH2, and its two partners EED and SUZ12; the second
complex, named PRC1, contains chromodomain mouse homologues of
Drosophila Polycomb, which bind to trimethylated H3K27 and to the two
interacting proteins PHC1 and RNF2. (A) A Venn diagram represents the
number of genes bound by each of these components and their overlap, showing
extensive colocalization among all members tested
(Boyer et al., 2006).
(B) A similar mapping for human embryonic stem cells identified a large
number of transcription factor-coding genes that can be grouped into major
developmental transcription factor families
(Lee et al., 2006). This
illustrates how PcG proteins regulate a variety of crucial developmental
patterning processes. Figure courtesy of Rudolf Jaenisch (Whitehead Institute
for Biomedical Research and Massachussets Institute of Technology, Cambridge,
MA, USA).
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