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Fig. 8. Asymmetry of Mash1 function in the development of dILA neurons.
Schematic diagram of progenitor cell divisions that generate a dILA daughter,
and a model of the Mash1 function in their development. (A)
dILA neurons are generated from progenitor cells by asymmetric cell divisions
in control mice (left). These divisions are either non-terminal (top) and
generate one dILA neuron and one progenitor, or are terminal (bottom) and
generate one dILA and one dILB neuron. In
Mash1–/– mice, aberrant progenitor cells (P*)
are formed at the expense of dILA neurons (right). Supernumerary dorsal
progenitors of Mash1–/– mice can incorporate
BrdU and do thus replicate, but many are subsequently eliminated by apoptosis.
(B) A model of Mash1 function in the development of dILA neurons that
arise by asymmetric terminal divisions. Mash1 is expressed in the progenitor
cell that gives rise to a dILA and a dILB neuron. In the dILA daughter,
Mash1 exerts essential functions for neurogenesis and lineage
specification. Mash1 allows a dILA progenitor (P1) to differentiate
(P1
N), and to express Ptf1a. By contrast, Mash1 is dispensable
for the development of the dILB lineage.
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