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Fig. 6. Environmental modulation of the sensitivity to DMPP. (A) DMPP
resistance of `genetically starved' worms. Surviving eat-6 and
pep-2 mutants on DMPP were scored 4 and 5 days after egg laying,
respectively. By this time, most mutants grown on control plates had reached
adulthood. (B) DMPP toxicity dose-response curves at 15, 20 and
25°C (wild-type N2 strain). (C) High pheromone concentrations
induce partial DMPP resistance at 20°C. As pheromone signaling is
antagonized by a food signal, animals were grown on plates lacking peptone,
which slightly decreases the quantity of available food
(Golden and Riddle, 1984a).
Error bar represents s.e.m., n=3 independent experiments. Dauer
larvae are not induced under these experimental conditions but pheromone
activity was tested independently for its ability to cause dauer formation
(data not shown).
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