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Fig. 7. Two independent timers can be differentially regulated at the L2
stage. Activation of nAChRs by DMPP slows developmental speed without
affecting the timing of molting, hence resulting in a lethal heterochronic
phenotype. The nuclear receptor DAF-12 bound to a hormonal ligand is necessary
to implement the developmental effect of nAChR activation. Environmental cues
that reduce the available amount of liganded-DAF-12 or that delay the L2/L3
molt protect the animals from DMPP-induced lethality (see the text for a full
discussion).
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