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Fig. 1. Structures of full-length and deleted Ft and Ds proteins. Shown are
the cleaved signal sequences (black), cadherin domains (purple), EGF-like
domains (green), Laminin-G domains (yellow-green), transmembrane domains
(light blue) and the HA tag (dark blue). Sites mutated in
ftfd and ftG-rv are also shown.
ftfd contains a stop codon in the 9th cadherin domain.
ftG-rv contains a mdg3 retrotransposon insertion
(the beginning of its sequence is underlined) that introduces a stop codon in
the 27th cadherin domain; it also contains additional rearrangements in the
first intron and a previously described insertion in the 33rd cadherin domain
(not shown) (Mahoney et al.,
1991).