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Figure 2


Fig. 2. Expression patterns of the MIS type I receptors (Alk2 and Alk3), Smad5 and P-SMAD in E15.5 rat urogenital ridges. (A,B) Whole-mount in situ hybridization shows decreased Alk2 expression in the cranial coelomic epithelium (A, arrow) and increased Alk3 expression in the mesenchyme (B, black arrowhead) of male urogenital ridges. White arrowhead indicates the coelomic epithelium. (C-F) Sexually dimorphic expression of P-SMAD detected by immunohistochemistry. (E,F) Higher magnifications of the boxed area around the Müllerian ducts in C,D. Arrowheads in D,F indicate P-Smad in mesenchyme surrounding Müllerian duct. (G,H) Smad5 expression detected in the coelomic epithelium (indicated by arrows) adjacent to the Müllerian duct of female (G) but not male (H) urogenital ridges. Cranial is oriented towards the top and Müllerian duct to the right of individual images (A,B). M, Müllerian duct; Ov, ovary; T, testis; W, Wolffian duct. Scale bar: 500 µm in A-D; 100 µm in E,F; 200 µm in G,H.





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