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Fig. 7. Schematics illustrating cardiovascular phenotypes resulting from the
differential ablation of Fgf8. (A) Normal Fgf8 expression
(green denotes normal Fgf8 expression domains). (B) Ablation
of Fgf8 in mesodermal precursors of the heart tube (red) and AHF
(blue) at the crescent/early somite stages generates small heart tubes and
prevents accrual of the RV/OFT myocardium, usually causing death. (C-E)
Compared with wild type (C), loss of mesodermal Fgf8 in surviving
Fgf8;MesP1Cre mutants and in Fgf8;Mef2cAHFCre mutants
disrupts OFT alignment resulting in TGA and DORV (D). Absence of Fgf8
in the endoderm and mesoderm disrupts septation and alignment, respectively,
resulting in PTA with an abnormally aligned truncal vessel (E).
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