QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 8, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Hes1 sets boundaries

The developing central nervous system is divided into compartments (which later form distinct populations of neurons) by boundary cells. These slowly proliferating, non-neuronal cells control neuronal specification in neighbouring compartments, but what regulates boundary formation? Baek and colleagues now report that persistent high levels of the bHLH transcription factor Hes1 regulate the formation of five boundaries (the floor plate, isthmus, rhombomere, roof plate and zona limitans intrathalamica boundaries) in the developing mouse brain (see p. 2467). They show first that Hes1 expression in non-boundary cells is variable but is always high in boundary cells. Then, by manipulating the expression of Hes1 in both cell types in vivo and in vitro, the researchers demonstrate that persistent high levels of Hes1 expression repress the expression of proneural transcription factors and reduce cell proliferation rates. Conversely, the absence of Hes1 (and also of Hes3 and Hes5) disrupts the organizing centres of the developing nervous system, thus confirming the importance of Hes1 expression in boundary formation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system

Joung Hee Baek, Jun Hatakeyama, Susumu Sakamoto, Toshiyuki Ohtsuka, and Ryoichiro Kageyama
Development 2006 133: 2467-2476. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?