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Figure 1


Fig. 1. Expression of Nodal agonists and antagonists between implantation and E5.5. (A) Nodal is already expressed at E4.5, both in the ICM and PrE of the blastocyst. Furin mRNA is expressed in the PrE lineage until E5.25, before it becomes restricted to the ExE and ExVE (E5.5). Pace4 and Cripto are specifically expressed in the trophectoderm lineage and epiblast, respectively. (B,C) The PrE also expresses the DVE markers Lefty1 (B), Hex and a HexP-GFP reporter transgene (C), whereas Cer1 mRNA is below detectable levels (B). Lefty1 and Hex transcripts are clearly downregulated between E5.0 and 5.25 before they reappear together with Cer1 mRNA in the most distal VE cells at E5.5.





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