QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 22, 2006

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Vasculogenesis and haematopoiesis: an early separation

It is widely thought that haemangioblasts are precursors for both blood cells and vascular endothelial cells. However, haematopoiesis and angiogenesis have not been analysed in detail in mouse embryos before embryonic day (E) 7.0 when haemangioblasts appear. Furuta and co-workers now report that the angioblast lineage diverges from mesoderm before, and independently of, haemangioblast formation (see p. 2771). Using in-vitro culture to evaluate vasculogenesis and haematopoiesis in cells taken from early mouse embryos, the researchers show that endothelial progenitors are present by E5.50 but stroma-dependent haematopoietic progenitors are not seen until E6.75; colony-forming units (the precursors of macrophages, erythrocytes and megakaryocytes) appear at E7.50. At this time, vasculogenic and haematopoietic precursors both express the transcription factor Oct3/4, which maintains the pluripotency of embryonic stem cells, but expression of CD31 (platelet endothelial cell adhesion molecule 1) divides them into angioblast (Oct3/4+, CD31-) and haemangioblast (Oct3/4+, CD31+) lineages. Thus, the authors conclude, there are distinct pathways for vasculogenesis and haematopoiesis that are independent of haemangioblasts.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo

Chie Furuta, Hideo Ema, Shin-ichiro Takayanagi, Takunori Ogaeri, Daiji Okamura, Yasuhisa Matsui, and Hiromitsu Nakauchi
Development 2006 133: 2771-2779. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?