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First published online June 22, 2006

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Chromatin-remodelling complexity in development

Chromatin remodelling regulates gene expression during development. Exactly how is not clear but a study of vulval development in Caenorhabditis elegans provides some important new clues (see p. 2695). Andersen, Lu and Horvitz report that a nucleosome remodelling factor (NURF)-like complex promotes the expression of vulval cell fates by antagonizing the action of synthetic multivulva (synMuv) genes, which repress gene transcription through chromatin remodelling. Simultaneous loss-of-function mutations in two synMuv genes - these include genes that encode chromatin-remodelling proteins and homologues of well-known transcription repressors such as Rb - produce worms with ectopic vulvae, indicating that synMuv proteins normally suppress vulval cell fates. The researchers show that ISW-1 (an orthologue of the Drosophila ATP-dependent chromatin remodelling enzyme ISWI) probably acts with NURF-1 (an orthologue of Drosophila NURF301) to promote the synMuv phenotype during vulval development. These results suggest that cell fate might be precisely regulated during development through the antagonistic chromatin-remodelling activities of transcriptional repressor complexes and NURF-like complexes.

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Related articles in Development:

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates

Erik C. Andersen, Xiaowei Lu, and H. Robert Horvitz
Development 2006 133: 2695-2704. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?