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First published online June 22, 2006

Development 133, 1404e (2006)
© The Company of Biologists Limited
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In this issue

Chromatin-remodelling complexity in development


Figure 1

Chromatin remodelling regulates gene expression during development. Exactly how is not clear but a study of vulval development in Caenorhabditis elegans provides some important new clues (see p. 2695). Andersen, Lu and Horvitz report that a nucleosome remodelling factor (NURF)-like complex promotes the expression of vulval cell fates by antagonizing the action of synthetic multivulva (synMuv) genes, which repress gene transcription through chromatin remodelling. Simultaneous loss-of-function mutations in two synMuv genes - these include genes that encode chromatin-remodelling proteins and homologues of well-known transcription repressors such as Rb - produce worms with ectopic vulvae, indicating that synMuv proteins normally suppress vulval cell fates. The researchers show that ISW-1 (an orthologue of the Drosophila ATP-dependent chromatin remodelling enzyme ISWI) probably acts with NURF-1 (an orthologue of Drosophila NURF301) to promote the synMuv phenotype during vulval development. These results suggest that cell fate might be precisely regulated during development through the antagonistic chromatin-remodelling activities of transcriptional repressor complexes and NURF-like complexes.


Related articles in Development:

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates
Erik C. Andersen, Xiaowei Lu, and H. Robert Horvitz
Development 2006 133: 2695-2704. [Abstract] [Full Text]  




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