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Fig. 2. Positive regulators of Drosophila JAK/STAT signalling.
(A) Three UPD-related ligands, each of which contain N-terminal signal
sequences (S) and have predicted N-linked glycosylation sites (dots).
(B) DOME contains fibronectin type III-like repeats (FN3)
(characteristic of cytokine receptors), a transmembrane region (blue box) and
a coiled-coil domain (cc). (C) Hopscotch contains an N-terminal FERM
(4.1, ezrin, radixin, moesin) domain found in all JAKs that is required for
association with the receptor (Usacheva
et al., 2002), an SH2 domain, a regulatory pseudo-kinase domain
and a Tyr kinase (Y-kinase) domain. (D) STAT92E contains a N-terminal
domain found in all STATs that mediates tetramerisation
(Johnson et al., 1999;
Vinkemeier et al., 1998), a
coiled-coil region and a DNA-binding domain (DBD). An SH2 domain is also
present, and is required for receptor binding and dimerisation. In mammalian
STATs, the C terminus also contains a transcriptional activation domain. In
NSTAT92E, the absence of the N-terminal region produces a protein that
acts as a dominant negative (Henriksen et
al., 2002). (E) BRWD3 contains eight WD40 motifs and two
BROMO domains, which are frequently present in chromatin-associated proteins.
Proteins and domains are shown to scale.
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