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Fig. 4. KEN selectively regulates STAT92E targets depending on the binding sites
present. (A) In vitro selection experiments have defined the
optimal DNA-binding sites of KEN and STAT92E. The `core' positions essential
for binding are shown in red (for KEN) or green (for STAT92E). There is
overlap in the sequences recognised. (B) Reporters differing only in
their STAT92E-binding sites respond differently to the activity of STAT92E and
KEN. In reporters to which only STAT92E can bind (green; top row), activation
by STAT92E cannot be modulated by KEN. When both STAT92E and KEN are able to
bind to a reporter (green and red; lower row), activation by STAT92E can be
countered by the co-expression of KEN. Neither reporter is active in the
absence of STAT92E. Green tick represents activation of reporter
transcription, red cross implies repression.
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