|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 5. JAK/STAT pathway activation leads to cellular overproliferation.
(A,B) Late third instar Drosophila larvae: (A) wild
type or (B) carrying a gain-of-function hop allele. Constitutively
activated JAK/STAT signalling leads to the proliferation of lamellocytes,
which aggregate to form prominent and, ultimately lethal, melanised tumours
(dark cells). (C) Wild-type and (D) upd-overexpressing
Drosophila eye imaginal discs, at the same magnification, are stained
to show the structure of the disc (red) and mitotic cells (green). The
morphogenetic furrow (MF) is marked, with the first and second mitotic waves
visible ahead and behind it. The increased density of mitotic cells in the
first mitotic wave is visible in the dorsal region of the
upd-overexpressing disc. (E,F) Scanning electron
micrographs of the adult eyes derived from (E) wild-type and (F)
upd-overexpressing Drosophila showing the dorsal overgrowth
of the adult eye that results from pathway mis-activation. (E) Reproduced,
with permission, from Bach et al. (Bach et
al., 2003).
|
